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by Turner, D.C. et al.The lack of a statistically significant drug-drug interaction agrees with preclinical findings suggesting that pazopanib does not influence the PK of metronomic...

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by Vergote, I. et al.Trebananib 10mg/kg and 15 mg/kg IV QW plus PLD or topotecan appear to have acceptable toxicity profiles in recurrent platinum-resistant or partially platinum-sensitive ovarian...

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by Allen, J.W. et al.Southwest Oncology Group S0802: a randomized, phase II trial of weekly topotecan with and without ziv-aflibercept in patients with platinum-treated small-cell lung cancer.J. Clin....

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by Stein, S.M. et al.Biweekly oxaliplatin plus a 14-day continuous IV infusion of topotecan, given monthly, is an active regimen in platinum-pretreated ovarian cancer and merits additional...

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by Walker, J. et al.Intraventricular topotecan for the treatment of neoplastic meningitis: five case studies.J. Adv. Pract. Oncol. 2012; 4:237-41[See paper]

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by Pinto, E.M. et al.Establishment and characterization of the first pediatric adrenocortical carcinoma xenograft model identifies topotecan as a potential chemotherapeutic agent.Clin. Cancer Res....

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by Callegaro-Filho, D. et al.We noted a sustained response in a patient with recurrent metastatic cervical cancer treated with radiotherapy, cisplatin, and topotecan followed by maintenance therapy...

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by Anderson, R.C. et al.Convection-enhanced delivery of topotecan into diffuse intrinsic brainstem tumors in children.J. Neurosurg. Pediatr. 2013; 3:289-95[See paper]

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by Li, M.H. et al.University of Connecticut Health Center, Center for Vascular Biology, Farmington, Connecticut, USAFTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan...

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by Zander, S.A. et al.Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, NetherlandsEZN-2208 (PEG-SN38) Overcomes ABCG2-Mediated Topotecan Resistance in BRCA1-Deficient Mouse...

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by Bączek, T. et al.Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416 Gdańsk, Poland. Electronic address: The primary goal was achieve the correct...

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by Trafalis, D.T. et al.Department of Pharmcology, University of Athens, Athens, GreeceTopotecan and pegylated liposomal doxorubicin combination as palliative treatment in patients with pretreated...

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by Li, D.D. et al.State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, ChinaThe Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53...

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by Altinbas, M. et al.Medical Oncology Clinic, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, TurkeyWeekly topotecan for recurrent small cell lung cancer - a retrospective anatolian...

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by Qaddoumi, I. et al.Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Pediatrics, TennesseeThe combination of topotecan and vincristine is effective...

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by McCluskey, A.G. et al.Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United KingdomInhibition of Poly(ADP-Ribose) Polymerase Enhances the Toxicity of...

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by von Gruenigen, V.E. et al.aDepartment of Obstetrics & Gynecology, Summa Akron City Hospital, Akron bDepartment of Obstetrics & Gynecology, Division of Gynecologic Oncology, USAToxicity of...

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by Tsang, P.S. et al.Oncogenomics Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, USA Furthermore, in a neuroblastoma xenograft mouse model, combined...

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by Kaiser, J. et al.Department of Pharmacy, University Medical Center of Johannes Gutenberg-University, Mainz, GermanyLoading profile of topotecan into polyvinyl alcohol microspheres (DC Bead™) over a...

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by Wiernik, P.H. et al. Single agent topotecan has moderate activity for previously treated high grade lymphoma equivalent to that of several newer agents, and should be considered for incorporation...

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by Perkins, J.B. et al.Text changed: *** Disease relevance of Hycamtin *** Mucositis was dose limiting and correlated with topotecan dose level and area under the curve (AUC) [Ref]. [See latest...

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by Ma, Y. et al.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China Unlike doxorubicin and mitoxantrone, the blood clearance rate of topotecan was dramatically rapid, and...

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by Yang, Y. et al.Shengjing Hospital of China Medical University, Shenyang, China Regarding the encapsulation efficiency of topotecan liposomes, both the pH value of the buffer and the cholesterol...

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by Park, J.R. et al.Seattle Children's Hospital, 4800 Sandpoint Way NE, Mailstop B6553, SeattlePilot Induction Regimen Incorporating Pharmacokinetically Guided Topotecan for Treatment of Newly...

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by Paik, P.K. et al.Memorial Sloan-Kettering Cancer Center, New York, NY, United StatesA phase II study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in relapsed small cell lung...

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by Andreopoulou, E. et al.Department of Medical Oncology, Breast Section, Montefiore Medical Center/Albert Einstein Cancer Center, 1825 Eastchester Road, USAPhase 1/pharmacology study of...

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by Sonabend, A.M. et al.Corresponding Author: Jeffrey N. Bruce, Neurological Institute, 710 West 168th Street, Room 434Prolonged intracerebral convection-enhanced delivery of topotecan with a...

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by Spigel, D.R. et al.Sarah Cannon Research Institute, Nashville, TN; Tennessee Oncology, PLLC, Nashville, TNA Phase II Study of Higher Dose Weekly Topotecan in Relapsed Small-Cell Lung Cancer.Clin....

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by Mallipatna, A.C. et al.FRCSC, Campbell Family Institute for Cancer Research, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, CanadaPeriocular topotecan in fibrin...

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by Manci, N. et al.A prospective phase II study of topotecan (Hycamtin®) and cisplatin as neoadjuvant chemotherapy in locally advanced cervical cancer.Gynecol. Oncol. 2011; 2:285-90[See paper]

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by Bakheet, S.A.Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. 2457, Saudi ArabiaPretreatment of mice with quercetin significantly reduced topotecan-induced...

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by Aljuffali, I.A. et al.University of Georgia, Athens, USAThese data support the hypothesis that low-dose continuous administration of topotecan increases potency compared to conventional dosing in...

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by McGonigle, K.F. et al.Women's Cancer Care of Seattle, Seattle, WashingtonCombined weekly topotecan and biweekly bevacizumab in women with platinum-resistant ovarian, peritoneal, or fallopian tube...

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by Hartwell, D. et al.Southampton Health Technology Assessments Centre, University of Southampton, First Floor Epsilon House, Enterprise Road, UKIntravenous topotecan was similar in efficacy to both...

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by Cormio, G. et al.Gynecologic Oncology Unit, Department of Gynecology, Obstetrics and Neonatology (DIGON), University of Bari, ItalyLong-term treatment with topotecan in recurrent/persistent ovarian...

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by Li, J. et al.Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, ChinaThe solvolysis of topotecan in alcohols and acetic anhydride.Bioorg. Med. Chem. Lett....

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by Aoki, D. et al.Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinjuku-ku, JapanA phase II clinical trial of topotecan in Japanese patients with relapsed ovarian...

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by Herzog, T.J. et al.Columbia University, New York Presbyterian Hospital, Department of OB/GYN, New York, USAThe weekly regimen of topotecan appeared less active but resulted in less toxicity than...

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by Ichinose, Y. et al.National Kyushu Cancer Center, 3-1-1, Notame, Minami-ku, JapanPhase I study of topotecan and cisplatin in patients with small cell lung cancer.Jpn. J. Clin. Oncol. 2011;...

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by Lopez, K.A. et al.Authors' Affiliations: Departments of Neurological Surgery, Pathology and Cell Biology, and Psychiatry, and the Herbert Irving Comprehensive Cancer Center, New...

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by Gonzalez, E.E. et al.Servicio de Oncología Médica, Medical Oncology Department, Hospital Universitario Central de Asturias, Julián Clavería, SpainActivity of topotecan given intravenously for 5...

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by Powell, S.F. et al.Bevacizumab in combination with topotecan as a salvage therapy for metastatic non--small-cell lung cancer is well tolerated and is worthy of further investigation.Clin. Lung....

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by Shah, D.K. et al. The model was linked to a toxicodynamic model for topotecan-induced weight-loss, and simulations were conducted to predict the effects of 8C2 on the toxicity of topotecan in...

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by Cruz-Muñoz, W. et al. The resistant phenotype is heritable, associated with reduced cellular uptake of topotecan and could not be reversed by switching to MTD topotecan or to another...

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by Hagmann, R. et al.Second-Line Therapy of Small-Cell Lung Cancer: Topotecan Compared to a Combination Treatment with Adriamycin, Cyclophosphamide And Vincristine (ACO) - a Single Center...

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by Surapaneni, K. et al.In this selected population of patients with recurrent malignant glioma treated with convection-enhanced delivery of topotecan, early changes in rCBV at 4 weeks after therapy...

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by Khalife, R. et al.Thymoquinone, when combined with topotecan in noncytotoxic doses, produced synergistic antiproliferative and proapoptotic effects in AML cells.Clin. Lymphoma. Myeloma. Leuk. 2014;...

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by Gholipour, M.A. et al.Intravitreal Topotecan Inhibits Laser-induced Choroidal Neovascularization in a Rat Model.J. Ophthalmic. Vis. Res. 2015; 3:295-302[See paper]

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by Kerklaan, B.M. et al. Topotecan had no effect on pazopanib concentrations.Br. J. Cancer. 2015; 5:706-15[See paper]

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by Sun, W. et al.Concurrent chemoradiotherapy with topotecan and cisplatin showed severe hematologic toxicity in intermediate-risk cervical cancer patients after radical hysterectomy.BMC. Cancer....

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